The Research Foundation for Microbial Diseases of Osaka University

“Tekijyuku”-a medical school in Osaka in late Edo era established by Koan Ogata, a physician- turned out many prominent persons such as Yukichi Fukuzawa and Masujiro Omura, who had greatly contributed to modernization of Japan.Many excellent doctors were brought up in“Osaka Jyoto-kan”, an adjunct facility of Tekijyuku, where vaccination against smallpox was begun.When we trace the roots of Faculty of Medicine of Osaka University, it connects with Tekijyuku through the network of Jyoto-kan. And, the Research Foundation for Microbial Diseases of Osaka University is descended from this glorious history.

The Research Foundation for Microbial Diseases of Osaka University annals

1934

6.	The Foundation was established in the compound of the Research Institute for Microbial Diseases, Osaka University,Dojima-Nishimachi,Kita-ku,Osaka.

1935

11.	The first production plant was settled at Ishibashi,Ikeda City, Osaka.
12.	Government approval for the manufacture of seven vaccines, typhoid, cholera, pertussis, small pox etc. was issued.

1938

6.	The first aid to academic research was given.

1945

The War ended.The Foundation contributed for the restoration of the national public health,supplying several kinds of vaccines.

1946

3.	Kanonji Institute was established at Kanonji City, Kagawa, for manufacturing typhus vaccine.

1952

3.	The first Japanese production of inactivated influenza vaccine was achieved.

1961

2.	The first Japanese production of inactivated polio vaccine was accomplished.

1962

4.	“Taniguchi Memorial Fellowship”,for young scientists in medical science,was established.

1965

10.	The ultracentrifuge-purified of Japanese encephalitis vaccine was completed and released.

1966

10.	The first Japanese production of inactivated measles vaccine was accomplished.
12.	The first measles vaccine live attenuated in Japan,was accomplished.

1967

12.	The Head Office of the Foundation removed to the new Suita campus of Osaka University, together with the Research Institute for Microbial Diseases,Osaka University.

1971

6.	Further-attenuated measles vaccine“BIKEN CAM”was accomplished.
8.	Manufacture of veterinary vaccines commenced in the newly established plant in Kanonji Institute.
10.	Inactivated Marek's disease vaccine for fowl was accomplished.

1972

8.	Live Marek's disease vaccine“BIKEN01”was accomplished.
9.	Influenza split vaccine, HA vaccine,was released.

1974

5.	Japanese encephalitis live vaccine for swine was accomplished.

1976

5.	Laboratory service for environmental health survey was started in Kanonji Institute.
12.	Rubella vaccine live attenuated was accomplished as the first one in Japan.

1981

1.	The first Japanese production of mumps(Urabe Am-9strain) vaccine live attenuated was accomplished.
4.	Inactivated porcine parvovirus vaccine was accomplished.
7.	The development of the acellular pertussis vaccine was accomplished and the new DPT vaccine was released.

1987

3.	The first Japanese production of the varicella vaccine(Oka strain) live attenuated was accomplished.

1989

3.	Measles/Mumps/Rubella combined vaccine live attenuated “BIKEN”was accomplished. Live porcine parvovirus vaccine was accomplished.

1992

5.	The first varicella skin test antigen was accomplished.
8.	US government approval for the production of acellular pertussis vaccine was issued.
12.	US government approval for the production lyophilized Japanese encephalitis vaccine was issued.

1993

6.	The recombinant hepatitis B vaccine (yeast derived) was approved.

1997

Japanese encephalitis,porcine parvovirus combined vaccine live attenuated was approved.

1998

12.	Inactivated iridovirus vaccine was approved.

2003

3.	Inactivated iridovirus-streptococcicosis combined vaccine was approved.

2004

3.	Kanonji laboratory ISO14001 acquisition.

2005

3.	Influenza HA vaccine "FLUBIK HA" was approved.
7.	Live Attenuated Measles and Rubella combined vaccine "MEARUBIK" was approved.

2006

6.	Adsorbed Diphtheria-purified Pertussis-Tetanus Combined Vaccine "TRIBIK" was approved.
7.	Adsorbed Diphtheria-tetanus Combined Toxoid "DT BIK" was approved.
8.	Adsorbed Diphtheria Toxoid for Adult Use "BIKEN F" was approved. Adsorbed Tetanus Toxoid "BIKEN F" was approved.

2007

10.	Adsorbed Influenza vaccine (H5N1) "BIKEN"（for Pre-pandemic flu） vaccine was approved.
12.	Inactivated Iridovirus-Streptococcicosis-Vibriosis combined vaccine was approved.

2008

11.	Influenza HA vaccine "FLUBIK HA Syringe" was approved.

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